lenalidomide6f

Lenalidomide-6-F is a derivative of Lenalidomide that serves as a cereblon (CRBN) ligand facilitating the recruitment of CRBN protein. With the addition of a linker, Lenalidomide-6-F can be conjugated to the ligand for the protein, enabling the formation of PROTAC.

Lenalidomide-6-F-piperidine-C2-Pip-C-COOH 作为PROTAC BTK Degrader-5的连接子和E3连接酶配体，在恶性淋巴瘤研究中具有应用潜力。