l. braziliensis

PK 11195 (RP 52028) 是一种用于神经成像的 TSPO 配体，对 CoCl2 诱导的改变表现出显着的保护能力，可用于研究利什曼病。

Piliformic acid is a fungal metabolite that has been found inN. pseudotrichiaand has diverse biological activities.1,2It is cytotoxic to BC-1 human breast cancer cells (IC50= 5 μg ml).2Piloformic acid is active againstL. braziliensisamastigotes (IC50= 78.5 μM). It is also active against the plant pathogenic fungiC. gloeosporioides(MIC = 292 μM).1 1.Elias, L.M., Fortkamp, D., Sartori, S.B., et al.The potential of compounds isolated from Xylaria spp. as antifungal agents against anthracnoseBraz. J. Microbiol.49(4)840-847(2018) 2.Cota, B.B., Tunes, L.G., Maia, D.N.B., et al.Leishmanicidal compounds of Nectria pseudotrichia, an endophytic fungus isolated from the plant Caesalpinia echinata (Brazilwood)Mem. Inst. Oswaldo Cruz113(2)102-110(2018)

Sitamaquine is an antileishmanial agent.1It is active againstL. donovani,L. infantum,L. mexicana,L. braziliensis, andL. tropica(EC50s = 9.5-19.8 μM). It inhibits mitochondrial complex II, also known as succinate dehydrogenase (SDH), in a cell-free assay when used at concentrations ranging from 10 to 200 μM.2Sitamaquine (100 μM) increases intracellular levels of reactive oxygen species (ROS) and decreases intracellular ATP levels, as well as induces phosphatidylserine externalization, chromatin fragmentation, and depolarization of the mitochondrial membrane potential, markers of apoptosis, inL. donovanipromastigotes. 1.López-Martín, C., Pérez-Victoria, J.M., Carvalho, L., et al.Sitamaquine sensitivity in Leishmania species is not mediated by drug accumulation in acidocalcisomesAntimicrob. Agents Chemother.52(11)4030-4036(2008) 2.Carvalho, L.J.M., Luque-Ortega, J.R., López-Martín, C., et al.The 8-aminoquinoline analogue sitamaquine causes oxidative stress in Leishmania donovani promastigotes by targeting succinate dehydrogenaseAntimicrob. Agents Chemother.55(9)4204-4210(2011)

PT4 可治疗皮肤利什曼病 (CL) ，它通过降低线粒体膜电位并增加活性氧的产生，从而寄生虫死亡。PT4 对两种利什曼原虫均产生效果，其对L. amazonensis 和L. braziliensis 的 IC50值分别为 125.18 和 233.18 μM。PT4 同时在体内具有有效的抗炎活性。

Antileishmanial agent-20 显示对利什曼原虫的选择性抑制作用，其针对L. infantum和L. braziliensis的IC50值分别为2.8 μM 和0.2 μM，适用于寄生虫研究领域。