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抑制剂&激动剂
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l threo ppmp

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    TargetMol | Inhibitors_Agonists
  • L-threo-PPMP
    T39478207278-87-3
    L-threo-PPMP is an inhibitor of GlcT, which is the UDP-Glc: Ceramide β1,1glucosyltransferase enzyme. It effectively inhibits glycosphingolipid biosynthesis, while also inducing apoptosis. These properties of L-threo-PPMP contribute to its notable anti-cancer activity.
    • ¥ 10600
    6-8周
    规格
    数量
  • DL-threo-PPMP
    T88952149022-18-4
    DL-threo-PPMP 作为一种抑制剂,有效地针对疟原虫 (Plasmodium falciparum) 中的鞘氨醇合成酶 (sphingosine synthetase).通过模拟鞘氨醇的底物,DL-threo-PPMP 与该酶结合,进而抑制其活性.这种作用导致宿主细胞内TVM的管状网络被选择性地破坏,并迅速降低了敏感的鞘氨醇合成酶活性,有效阻断疟原虫的繁殖过程.DL-threo-PPMP 常被应用于疟原虫生物学研究及新型抗疟策略的开发.
    • 待询
    10-14周
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  • D-threo-PPMP hydrochloride
    T36974139889-65-9
    D-threo-PPMP is a glucosylceramide (GlyCer) synthetase inhibitor.1,2It is the active enanantiomer and enzymatic inhibitory component of the racemic DL-threo-PPMP . In MDCK kidney epithelial cells, D-threo-PPMP induces a 70% reduction in cell growthin vitroat 20 μM and significantly inhibits DNA synthesis at 3 μM.3[Matreya, LLC. Catalog No. 1865] 1.Shen, W., Henry, A.G., Paumier, K.L., et al.Inhibition of glucosylceramide synthase stimulates autophagy flux in neuronsJ. Neurochem.129(5)884-894(2014) 2.Lee, L., Abe, A., and Shayman, J.A.Improved inhibitors of glucosylceramide synthaseJ. Biol. Chem.274(21)14662-14669(1999) 3.Abe, A., Inokuchi, J.-i., Jimbo, M., et al.Improved inhibitors of glucosylceramide synthaseJ. Biochem.111(2)191-196(1992)
    • 待估
    35日内发货
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