kir2.1

Zacopride hydrochloride 是5-HT3受体拮抗剂 (Ki:0.38 nM)，也是5-HT4受体激动剂 (Ki:373 nM)，具有抗焦虑作用。它对精神分裂症具有潜在的研究价值。

ML133 hydrochloride (ML133 HCl) 是选择性的Kir2家族通道抑制剂，在pH 7.4 和pH 8.5 时的IC50值分别为1.8 μM 和290 nM。

VU591 hydrochloride 是选择性的肾外髓钾通道抑制剂，IC50为 0.24 μM。

IK1 inhibitor PA-6 是一种喷他脒类似物，是选择性的 IK1(KIR2.x 离子通道携带向内整流电流) 抑制剂，对人和老鼠中 KIR2.x 电流的 IC50值为 12-15 nM。它可上调 KIR2.1 的蛋白表达，诱导细胞内 KIR2.1 的蛋白的积累。它在房颤和心律失常的研究中具有潜力。

VU041 is an inhibitor of Anopheles gambiae and Aedes aegypti inward rectifier potassium 1 channels (IC50: 2.5 μM and 1.7 μM, respectively). VU041 inhibits appreciably is mammalian Kir2.1 (IC50: 12.7 μM) and has less inhibitory effect on mammalian Kir1.1, Kir4.1, Kir6.2 SUR1, and Kir7.1.

ML 297 是选择性的 GIRK1 2激活剂，EC50为 0.16 μM。ML 297 在癫痫病的研究中具有价值。

Lei-Dab7 TFA, a selective and high-affinity blocker of the K Ca 2.2 (SK2) channel with a dissociation constant (K d) of 3.8 nM, demonstrates over 200-fold selectivity for K Ca 2.2 compared to K Ca 2.1, K Ca 2.3, K Ca 3.1, K v, and Kir2.1. Furthermore, Lei-Dab7 TFA enhances theta-burst responses and long-term potentiation (LTP) in rat hippocampal slices in vitro.

High affinity, selective KCa2.2 (SK2) channel blocker (Kd = 3.8 nM). Exhibits >200-fold selectivity for KCa2.2 over KCa2.1, KCa2.3, KCa3.1, IK, Kv and Kir2.1. Increases theta-burst responses and increases LTP in rat hippocampal slices in vitro. Convulsive