jpi547

Fasoracetam monohydrate is a small synthetic molecule and a metabotropic glutamate receptor activator, which has previously undergone extensive Phase I-III clinical trials in humans for vascular dementia.

Nesuparib (JPI-547 OCN-201) 是一种有效的PARP抑制剂，对PARP 和TNKS1具有抑制作用。Nesuparib 具有抗肿瘤活性，可用于治疗肿瘤、内分泌与代谢疾病、泌尿生殖系统疾病，可用于研究神经性疼痛、神经退行性疾病和心血管疾病 。

JPI 547, also known as NOV 1402, is an oral inhibitor of PARP 1 2 and Tankyrase 1 2. JPI-547 demonstrated anti-tumor activity in BRCA-deficient xenograft models as a single-agent and in combination with chemotherapy and immune checkpoint inhibitors.