Jolkinolide A has anti-tumor activity. It inhibited VEGF expression in A549 cells through the inhibition of the Akt-STAT3-mTOR signaling pathway, and directly inhibited the proliferation and migration of HUVECs.
17-Hydroxyjolkinolide A (Caudicifolin; Fischeriana A) 是一种从大戟根中提取的昆虫摄食抑制剂。它能有效诱导玉米夜蛾 (S. zeamais) 与赤霉成虫 (T. castaneum) 对谷物产生拒食行为,其EC50s 值分别为 631.9 ppm 和 656.5 ppm。