jnj 61803534

PDE1-IN-1can enhance levels of the second messengers cAMP cGMP leading to the expression of neuronal plasticity-related genes, neurotrophic factors, and neuroprotective molecules. These neuronal plasticity enhancement properties make PDE1 inhibitors good candidates as therapeutic agents in many neurological conditions.

JNJ-61803534 是一种有效的、具有口服活性 RORγt 反向激动剂，IC50为 9.6 nM。JNJ-61803534 具有抗炎活性。JNJ-61803534 在 Th17 分化条件下抑制人 CD4+ T 细胞产生 IL-17A。