interval

SKF-96365 hydrochloride (SKF96365) 是store-operated Ca2+entry 抑制剂，也是TRP channel 阻滞剂。它显著抑制豚鼠离体心脏 hERG、hKCNQ1 hKCNE1、hKir2.1 和 hKv4.3 电流，延长QTc 间期。它通过诱导结直肠癌细胞的细胞周期阻滞和凋亡起抗肿瘤作用。

Lidoflazine is a high-affinity blocker of the HERG K+ channel and is an antianginal calcium channel blocker. It carries an obvious risk of QT interval prolongation and ventricular arrhythmia.

Belaperidone is an antipsychotic drug. It has a clozapine-like receptor profile and affinities for dopamine D(4) and 5-hydroxytryptamine(2A) receptors. LU111995 prolongs the Q-T interval to a limited degree and is not arrhythmogenic over the physiological

Ibutilide Fumarate (U70226E) 是一种 III 类抗心律失常药物，可作用于急性心梗阻塞。

Eleclazine(GS-6615)是一种新型和选择性的电压门控钠离子通道抑制剂，具有抗心律失常的作用，减少对人诱导多能干细胞来源的心肌细胞记录的峰值钠电流。

BeKm-1 TFA is a potent, selective blocker of the KV11.1 (hERG) channel, demonstrating specificity for KV11.1 over 14 other potassium channels. This compound dose-dependently prolongs the QTc interval in isolated rabbit hearts, affirming its role as a selective inhibitor.

Linoleoyl ethanolamide phosphate is an intermediate in the biosynthesis of linoleoyl ethanolamide, generated through phospholipase C-mediated hydrolysis of N-acylphosphatidylethanolamine. Linoleoyl ethanolamide phosphate, along with other endogenous N-acylethanolamines, is thought to regulate food intake by selectively prolonging feeding latency and post-meal interval [Linoleoyl Ethanolamide Phosphate].

WIZ degrader 1 (Compound 141) 作为一种宽间隔锌指基序 (WIZ) 的降解剂，其AC50值达到2 nM。此化合物还能有效诱导胎儿血红蛋白 (HbF) 的表达，其EC50为6 mM。该化合物主要用于遗传性血液疾病的研究。

WIZ degrader 2 (Compound 142) 作为一种新型宽间隔锌指基序 (WIZ) 降解剂,具备显著的活性,其AC50值为0.011 μM.此化合物通过诱导胎儿血红蛋白 (HbF) 的表达,显示出良好的生物学效果,其EC50值为0.038 μM.WIZ degrader 2 主要应用于遗传性血液疾病相关的研究领域.

WIZ degrader 3 (Compound 29) 作为宽间隔锌指基序 (WIZ) 的降解剂,展现出AC50值为 6.4 nM 的高效性.此外,该化合物还能促进胎儿血红蛋白 (HbF) 的表达,其EC50值为 45 nM.WIZ degrader 3 主要应用于研究血液疾病,包括镰状细胞病和 β-地中海贫血等.

Potent and selective KV11.1 (hERG) channel blocker. Selective for KV11.1 over a panel of 14 other potassium channels. Dose-dependently prolongs QTc interval in isolated rabbit heart.