inha-in-2

InhA-IN-2直接抑制 InhA，不需要过氧化氢酶过氧化物酶 KatG 的激活。

VEGFR-2 InhA-IN-1是一种含吡唑结构的双功能抑制剂，既具有抗结核活性也有抗血管生成的效用。该化合物对结核分枝杆菌H37Rv株展示出有效的抑菌作用（MIC=6.25 μg mL），同时对VEGFR-2的抑制也相当显著（IC50=15.27 nM）。

InhA-IN-9 (compound 7h) 是一种结核分枝杆菌InhA（烯酰 ACP 还原酶）的抑制剂，并能够结合InhA。在MIC值为2 μg mL时，InhA-IN-9显示出抗结核活性。

Pyridomycin is a structurally unusual antimycobacterial cyclodepsipeptide whose composition includes two rare moieties: 3-(3-pyridyl)-L-alanine and 2-hydroxy-3-methylpent-2-enoic acid. It inhibits NADH-dependent enoyl (Acyl-Carrier-Protein) reductase InhA, preventing mycolic acid synthesis in M. tuberculosis, including isoniazid-resistant strains (MICs = 0.31-0.63 μg ml).