infectious skin diseases

Azathioprine (BW 57-322) 是一种免疫抑制剂。

Anti-MRSA agent 32 (Compound 26) 是一种选择性激活剂，具备口服活性，针对SaClpP (Staphylococcus aureus ClpP蛋白酶) 的EC50值为0.98 μM。通过激活SaClpP蛋白酶，它能异常降解细菌蛋白，从而抑制Staphylococcus aureus的增殖。在小鼠皮肤感染模型中，Anti-MRSA agent 32 促进伤口愈合，显示出在耐甲氧西林Staphylococcus aureus (MRSA) 等感染性疾病研究中的潜力。

Lanopepden, also known as GSK-1322322 or GSK-322, is a potent and selective peptide deformylase inhibitor with good in vitro activity against bacteria associated with community-acquired pneumonia and skin infections. GSK1322322 had bactericidal activity against S. pneumoniae, H. influenzae, S. pyogenes, and S. aureus, demonstrating a ≥ 3-log(10) decrease in the number of CFU/ml at 4× MIC within 24 h in 29 of the 33 strains tested. GSK1322322 represents a valuable alternative therapy for the treatment of infectious diseases caused by drug-resistant pathogens.