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TargetMol产品目录中 "

ilk in 3

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  • 抑制剂&激动剂
    2
    TargetMol | Inhibitors_Agonists
  • 重组蛋白
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    TargetMol | Recombinant_Protein
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    TargetMol | Antibody_Products
  • ILK-IN-3
    T85236975-75-3
    ILK-IN-3 是一种整合素连接激酶抑制剂,具有抗肿瘤活性。
    • ¥ 546
    现货
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    TargetMol | Inhibitor Sale
  • QLT0267
    T84998866409-68-9
    QLT0267 is an inhibitor targeting integrin-linked kinase (ILK; IC50= 26 nM), showing over 10-fold selectivity against cyclin-dependent kinases 1, 2, and 5 (Cdk1, Cdk2, and Cdk5), and over 1,000-fold selectivity against C-terminal Src kinase (CSK), DNA-PK, Pim-1, Akt, PKC, and casein kinase 2 (CK2) at a concentration of 10 mg/ml. This compound effectively inhibits the proliferation of NPA187 papillary thyroid cancer cells with an IC50 of approximately 3 µM and induces apoptosis in NPA187, DRO, and K4 cancer cell lines. In vivo studies reveal that QLT0267, administered at 100 mg/kg, significantly reduces tumor growth in a DRO mouse xenograft model and diminishes both tumor volume and intratumoral vascularization in a U87MG glioblastoma mouse xenograft model, showcasing its potential for therapeutic applications in cancer treatment.
    • ¥ 1790
    35日内发货
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