i xw 053

I-XW-053 sodium inhibits the replication of a diverse panel of primary HIV-1 isolates in Peripheral blood mononuclear cell with no appreciable cytotoxicity.

I-XW-053 是一种针对衣壳的 HIV-1 复制抑制剂，使用基于混合结构的方法以微摩尔亲和力阻断 CA N 末端结构域之间的界面（NTD-NTD 界面）。

CK176 is a capsid targeted inhibitor of HIV-1 replication. CK176 shows an 11-fold improvement over I-XW-053 in blocking HIV-1 replication in primary human peripheral blood mononuclear cells (PBMCs).