human multiple myeloma tumor

GSK467 是一种有效的、选择性的 KDM5 (JARID1) 抑制剂，Ki 值为10 nM。

PC-046 is a potent tubulin-binding agent, which was originally identified for development based on selective activity in deleted in pancreas cancer locus 4 (DPC4/SMAD4) deficient tumors. PC-046 has growth inhibitory activity in a variety of tumor types in vitro, and efficacy in SCID mice was shown in human tumor xenografts of MV-4-11 acute myeloid leukemia, MM.1S multiple myeloma, and DU-145 prostate cancer. Pharmacokinetic studies demonstrated relatively high oral bioavailability (71 %) with distribution to both plasma and bone marrow. No myelosuppression was seen in non-tumor bearing SCID mice given a single dose just under the acute lethal dose. The COMPARE algorithm in the NCI-60 cell line panel demonstrated that PC-046 closely correlated to other known tubulin destabilizing agents (correlation coefficients ≈0.7 for vincristine and vinblastine). Mechanism of action studies showed cell cycle arrest in metaphase and inhibition of tubulin polymerization. Overall, these studi......

Linvoseltamab是一种全人源BCMA和CD3双特异性T细胞衔接抗体，通过同时结合多发性骨髓瘤细胞表面的B细胞成熟抗原(BCMA)和T细胞表面的CD3，诱导T细胞定向杀伤肿瘤细胞，在复发/难治性多发性骨髓瘤的治疗机制研究中具有重要作用。

Tumour-associated MUC1 epitope是一种具有标志性的生物活性肽。作为高度糖基化的I型跨膜糖蛋白MUC1的一部分，该肽通过特定的胞外结构域展现，该结构域包含20个氨基酸组成的可变数量串联重复序列(VNTR)。在多种人类腺癌及血液恶性肿瘤（如多发性骨髓瘤和B细胞淋巴瘤）中细胞表面表达过量，因此，MUC1是许多免疫治疗策略的关键靶点。

MSH-TP15e 是一种针对细胞间黏附分子-1 (ICAM-1) 的人源单克隆抗体抑制剂，通过招募自然杀伤细胞，有效引发抗体依赖性细胞介导的细胞毒性 (ADCC) 作用，从而抑制肿瘤细胞生长。该化合物有潜力用于多发性骨髓瘤 (MM) 的研究。

Ramantamig 是一种人源化单克隆抗体，专门靶向人CD3ε、GPRC5D和TNFRSF17 (肿瘤坏死因子受体超家族成员 17)。Ramantamig 可能在癌症研究中具有应用潜力，特别是在血液系统恶性肿瘤 (如多发性骨髓瘤) 的研究中。