hsp40

p5 Ligand for Dnak and DnaJ acetate(209518-24-1 free base) 是一种九肽。它是 DnaK（大肠杆菌 Hsp70）和 DnaJ（大肠杆菌 Hsp40）的高亲和力配体。

ML346是 Hsp70和 HSF-1活性的激活剂，针对 Hsp70 的 EC50为 4.6 μM。它诱导热休克反应 (HSR) 的基因和蛋白质效应子的特异性增加，如 Hsp70、Hsp40 和 Hsp27。

KNK437 (Heat Shock Protein Inhibitor I) 是一种 HSP 抑制剂，抑制 HSP40，HSP70 和 HSP105 的活化。

Heat shock protein (Hsp) inhibitor II is the active form of Hsp inhibitor I and a benzylidene lactam compound that prevents the synthesis of inducible Hsps, such as Hsp105, Hsp72, and Hsp40. Hsp inhibitor II decreases Hsp72 synthesis in vivo and reduces thermotolerance of tumors in SCC VII tumor-containing mice. At 100 μM, it inhibits the development of thermotolerance in COLO 320 DM cells. Inhibition of Hsp70 with Hsp inhibitor II in combination with amphotericin B increases susceptibility of AmB-susceptible (MICs = 0.058 versus 0.27 μg ml for combined and AmB alone, respectively) and AmB-resistant (MICs = 21.33 versus >32 μg ml for combined and AmB alone, respectively) strains of A. fumigatus.