hppd

Mesotrione 是一种苯甲酰环己二酮类除草剂，是一种竞争性羟基苯基丙酮酸双加氧酶酶抑制剂。它对玉米作物具有选择性，它在易感作物中代谢速度快，耐受性较高。

Sulcotrione 属于β-三酮类除草剂，对羟基苯基丙酮酸双加氧酶有抑制作用。

HPPD-IN-1 (compound II-3)为一种有效的HPPD抑制剂，其对拟南芥HPPD (AtHPPD)的IC50为0.248 μM，表现出优于mesotrione的抑制效果（其IC50为0.283 μM）。此外，HPPD-IN-1对阔叶和单子叶杂草均展现出杰出的除草性能。

HPPD-IN-3（compound 25） 是一种有效的 4-羟苯基丙酮酸双加氧酶（HPPD）抑制剂，其 IC50 值为 10 nM，比 Mesotrione 更具效能。

HPPD-IN-4 (Compound III-29) 作为HPPD选择性抑制剂，其IC50值为0.19 μM，主要应用于高效除草剂的研发中。

Benzobicyclon(苯并双环酮)是一种 4-hydroxyphenylpyruvate dioxygenase (4-HPPD)抑制剂和除草剂，对一年生草、莎草和阔叶杂草具有光谱活性，而对水稻没有毒性。

AtHPPD-IN-1 (Compound III-15) 是一种HPPD抑制剂和除草剂，并且对花生具有良好的安全性。AtHPPD-IN-1 对拟南芥HPPD的IC50为12 nM。

Cypyrafluone, 作为一种4-羟基苯丙酮酸双加氧酶(4-HPPD)抑制剂，能有效阻止尿黑酸(HGA)的生成。

Nitisinone-13C6is intended for use as an internal standard for the quantification of nitisinone by GC- or LC-MS. Nitisinone is an inhibitor of 4-hydroxyphenylpyruvate dioxygenase (HPPD), which converts 4-hydroxyphenylpyruvate (HPPA) to homogentisate in the tyrosine catabolic pathway.1Nitisinone increases urinary levels of HPPA and 4-hydroxyphenyllactate (HPLA) in rats when administered at a dose of 10 mg kg. Nitisinone (3 mg kg) prevents the neonatal lethality of fumarylacetoacetate hydrolase (FAH) deficiency in mice when administered to pregnant dams.2It exhibits hepatoprotective effects inFAH- -mice, such as prevention of increases in plasma levels of aspartate serine aminotransferase (AST) and conjugated bilirubin, when administration is continued following birth at a dose of 1 mg kg. Nitisinone (100 μg) decreases urinary excretion of homogentisate and increases urinary excretion of HPPA, HPLA, and 4-hydroxyphenylacetate in a mouse model of alkaptonuria induced by ethylnitrosourea.3Formulations containing nitisinone have been used in the treatment of hereditary tyrosinemia type 1 (HT-1). 1.Ellis, M.K., Whitfield, A.C., Gowans, L.A., et al.Inhibition of 4-hydroxyphenylpyruvate dioxygenase by 2-(2-nitro-4-trifluoromethylbenzoyl)-cyclohexane-1,3-dione and 2-(2-chloro-4-methanesulfonylbenzoyl)-cyclohexane-1,3-dioneToxicol. Appl. Pharmacol.133(1)12-19(1995) 2.Grompe, M., Lindstedt, S., al-Dhalimy, M., et al.Pharmacological correction of neonatal lethal hepatic dysfunction in a murine model of hereditary tyrosinaemia type INat. Genet.10(4)453-460(1995) 3.Suzuki, Y., Oda, K., Yoshikawa, Y., et al.A novel therapeutic trial of homogentisic aciduria in a murine model of alkaptonuriaJ. Hum. Genet.44(2)79-84(1999)

Topramezone为高效的4-羟基苯基丙酮酸双加氧酶(4-HPPD)抑制剂，作为除草剂(herbicide)，适用于防治玉米中的阔叶杂草和禾本科杂草出苗后。

Fenquinotrione为4-羟基苯丙酮酸双加氧酶(HPPD)抑制剂，水稻HPPD (OsHPPD) 及拟南芥HPPD (AtHPPD) 的IC50分别达27.2及44.7nM。此化合物作为除草剂，对多种阔叶及芦苇杂草具有广泛防治效果，并展现出对水稻的高选择性。

Brassicanate A sulfoxide 表现出除草效果，它能抑制植物中必需氨基酸的生物合成路径。该化合物通过结合并抑制多种酶的活性来发挥其作用，包括二羟酸脱水酶 (DHAD)、羟甲基丙酮酸双加氧酶 (HPPD)、乙酰乳酸合酶 (ALS)、PYL家族蛋白及转运抑制剂响应 1 (TIR1)。Brassicanate A sulfoxide 可以从甘蓝 (Brassica oleracea) 中提取获得。