Hexamethoniumchloride is a preferential nicotinic receptor blocker at the level of autonomic ganglia. It has been shown to cross the blood-brain barrier only in high doses.
Hexamethoniumchloride dihydrate is a non-depolarizing NMJ blocker and nAChR antagonist. It has previously been used to treat hypertension. It inhibits sympathetic nervous system activity and acts as a skeletal muscle relaxant.