helminths

Nitazoxanide (NSC-697855) 是一种广谱驱虫剂，对感染动物和人类的各种蠕虫、原生动物和肠道细菌都具有作用活性。 它在无菌培养中抑制Giardia lamblia 滋养体增殖，IC50为 2.4 μM。它可研究寄生虫性胃肠炎，具有抗病毒特性。

Ascaridole (NSC-406266) 可作为驱虫化合物，能驱除人体和植物中的寄生蠕虫(蠕虫)，具有较弱的抗疟活性。

GSK J5 对血吸虫和蠕虫具有抑制作用，常被当作一种吸血虫杀虫剂。GSK J5 以剂量和时间依赖的方式促进血吸虫死亡。GSK J5 可提高血吸虫死亡率、减低成虫活力。

2-Aminoflubendazole, a metabolite of benzimidazoles (BZ), belongs to a class of drugs effective against fungi, protozoa, and helminths.

Albendazole-D7 is intended for use as an internal standard for the quantification of albendazole by GC- or LC-MS. Albendazole (T1152) is an orally bioavailable benzimidazole anthelmintic that is active against a variety of helminths,including liver flukes,tapeworms,and roundworms. It eliminates Trichostrongylus in the fourth stomach of cattle and sheep when orally administered at doses ranging from 2.5 to 10 mg/kg as well as other species in the fourth stomach and the small and large intestine. Albendazole (T1152) (0.05% in the diet)protects mice against lethal infection with A. suum larvae. It also inhibits growth of HT-29 human colorectal cancer cells (IC50 = 0.12 µM),halts the cell cycle at the G2/M phase,and induces apoptosis. In an HT-29 mouse xenograft model,it inhibits peritoneal tumor growth when administered intraperitoneally at a dose of 150 mg/kg but not when administered orally. Albendazole (T1152)inhibits mammalian tubulin polymerization and inhibits binding of [3H]mebendazole t......