hbv-in-4

HBV-IN-4, a derivative of phthalazinone, functions as a potent, orally active inhibitor of HBV DNA replication, exhibiting an IC50 value of 14 nM. It effectively induces the formation of genome-free capsids, demonstrating significant anti-HBV potency[1].

HBV-IN-43 (compound 5832) 是一种高效的HBV抑制剂。

HBV-IN-46 (compound 1.6),一种具有显著生物活性的代谢物,作为HBVS抗原的抑制剂效能显著,其EC50值仅为2.6 nM.

HBV-IN-47 (compound 4a) 为衣壳组装调节剂,用于研究慢性乙型肝炎 (CHB),该化合物在抑制乙型肝炎病毒 (HBV) 中表现出显著活性.在HepAD38细胞实验中,HBV-IN-47 显示出高效的抗HBV效果,同时具有低毒性 (EC50=0.24 μM).

HBV-IN-48 为HBV抑制剂。该化合物在 HepDE19 细胞中表现出抗HBV活性，其EC50为 0.005 μM。此外，HBV-IN-48 在HBV感染小鼠模型中能有效降低血清HBVDNA含量。

HBV-IN-41（化合物45）是一种口服活性乙型肝炎病毒（HBV）抑制剂，具有高效性，其EC50值为0.027μM。

HBV-IN-40（Compound 11826096）是一种具有IC50值为0.7 μM的HBV抑制剂，同时也是一种抗病毒药物。

Isothiafludine (NZ‐4) 是一种具有口服活性的抗 HBV 化合物。Isothiafludine 通过阻断基因组前RNA（pgRNA）的包封和干扰核衣壳组装来发挥作用，可用于研究 HBV 感染。

Helioxanthin derivative 5-4-2 （Helioxanthin 5-4-2） 是螺旋黄质的类似物，在体外显示出抗 HBV 活性，可用于研究HBV。

1,2,3,4,6-O-Pentagalloylglucose (Penta-O-galloyl-β-D-glucose) 存在于多种植物中，具有重要的药理作用。Pentagalloylglucose 表现出显著的抗狂犬病病毒 (RABV) 活性。

Swertianolin (Bellidifolin-8-O-Glucoside) 是从Gentianella Acuta 分离得到的一种黄酮，具有抗 HBV 和抗菌活性，可抑制乙酰胆碱酯酶。

Destruxin B2 is a cyclic hexadepsipeptide mycotoxin that has been found in M. anisopliae and has antiviral, insecticidal, and phytotoxic activities.1,2,3 It inhibits secretion of hepatitis B virus surface antigen (HBsAg) by Hep3B cells expressing hepatitis B virus (HBV) DNA (IC50 = 1.3 μM).1 Destruxin B2 is toxic to Sf9 insect cells in an electric cell-substrate impedance sensing (ECIS) test with a 50% inhibitory concentration (ECIS50) value of 92 μM.4 It is also phytotoxic to B. napus leaves.3 |1. Yeh, S.F., Pan, W., Ong, G.-T., et al. Study of structure-activity correlation in destruxins, a class of cyclodepsipeptides possessing suppressive effect on the generation of hepatitis B virus surface antigen in human hepatoma cells. Biochem. Biophys. Res. Commun. 229(1), 65-72 (1996).|2. Male, K.B., Tzeng, Y.-M., Montes, J., et al. Probing inhibitory effects of destruxins from Metarhizium anisopliae using insect cell based impedance spectroscopy: Inhibition vs chemical structure. Analyst 134(7), 1447-1452 (2009).|3. Buchwaldt, L., and Green, H. Phytotoxicity of destruxin B and its possible role in the pathogenesis of Alternaria brassicae. Plant Pathol. 41(1), 55-63 (1992).

HBV-IN-21 (Compound II-8b) is a potent inhibitor of HBV DNA replication, exhibiting an IC50 of 2.2 μM. It demonstrates a favorable binding affinity (K D = 60.0 μM) for the HBV 4 capsid protein, thereby enabling effective interaction [1].

HBV HDV-IN-4 hydrochloride (Compd 4) 作为HBV与HDV的双重抑制剂，展示了在针对HBV的抑制上具有卓越的活性，其EC50值均低于50 nM。

TLR8 agonist 4 能够有效的抑制野生型和耐药（拉米夫定和恩替卡韦）HBV 菌株，他们的IC50值分别为 0.15 和 0.10 μM。