hat1

BMS-248360 is a potent and orally active dual antagonist of both angiotensin II receptor (AT1) and endothelin A (ETA) receptor. With Kis of 10 nM and 1.9 nM for hAT1 and hETA receptor, respectively. BMS-248360 shows hypertensive effects[1].

JG-2016，作为一种小分子组蛋白乙酰转移酶1 (HAT1) 抑制剂，抑制人类癌细胞系的生长，抑制纤维素中的酶活性，干扰肿瘤生长。