ha-23

HA-23 is a Ca(2+)-channel blocker.

Lanopepden, also known as GSK-1322322 or GSK-322, is a potent and selective peptide deformylase inhibitor with good in vitro activity against bacteria associated with community-acquired pneumonia and skin infections. GSK1322322 had bactericidal activity against S. pneumoniae, H. influenzae, S. pyogenes, and S. aureus, demonstrating a ≥ 3-log(10) decrease in the number of CFU/ml at 4× MIC within 24 h in 29 of the 33 strains tested. GSK1322322 represents a valuable alternative therapy for the treatment of infectious diseases caused by drug-resistant pathogens.

alpha-2-3,6-sialidase (BiNanH2) 为一种生化研究常用的唾液酸转移酶，催化 α-2,3/2,6-唾液酸从 CMP-Neu5Ac 转移到半乳糖苷受体。

VF-57a (Compound 23) 是一种甲型流感病毒 (IAV) 融合抑制剂，在真实的 A/H1N1 病毒中展现出了显著的抗病毒活性，对 A/H1N1 PR8 和 A/H1N1 Virg09 毒株的EC50分别为 0.92 μM 和 0.31 μM。VF-57 能有效抑制 HA 介导的 A/H1N1 和 A/H5N1 假病毒侵入细胞，并在 pH 5.2 时阻止 HA 结构重新折叠。VF-57a 可以用于研究 IAV 感染。