gliclazide

Gliclazide (SE1702) 是一种有效的全细胞的 β 细胞 ATP 敏感型钾流阻断剂，IC50为 184 nM，用作降糖药。

Gliclazide-D4 is intended for use as an internal standard for the quantification of gliclazide by GC- or LC-MS. Gliclazide (T1527) is a sulfonylurea and an inhibitor of pancreatic β-cell ATP-sensitive potassium (KATP)channels. It is selective for pancreatic β-cell over cardiac and arterial smooth muscle cell KATP channels. Gliclazide (T1527) (5 μM)increases insulin-induced glucose uptake and glucose transporter 4 (GLUT4)translocation to the plasma membrane in a differentiated 3T3L1 adipocyte model of insulin resistance induced by hydrogen peroxide. Gliclazide (T1527) (5 and 10 μg/ml)reduces LDL oxidation by human aortic smooth muscle cells (HASMCs),decreasing TBARS content and 8-isoprostane levels. It also decreases oxidized LDL-induced HASMC proliferation and monocyte adhesion when used at concentrations ranging from 1 to 10 μg/ml. Gliclazide (T1527) (5 mg/kg)reduces serum glucose levels and increases glucose uptake by isolated rat hindquarters in a model of diabetes induced by streptozotocin (STZ).

Gliclazide-D7是Gliclazide (T1527)的氘代化合物。Gliclazide的CAS号为21187-98-4。Gliclazide是一种有效的全细胞的 β 细胞 ATP 敏感型钾流阻断剂，IC50为 184 nM，用作降糖药。

Gliclazide-D4 (Standard) 是 Gliclazide-D4 的标准品，适用于定量分析、质量控制及生化实验等相关研究。Gliclazide-d4 用于通过气相色谱-质谱法或液相色谱-质谱法对Gliclazide进行定量分析时作为内标物。Gliclazide是一种磺酰脲类药物，能抑制胰腺β细胞的 ATP 敏感性钾（KATP）通道。它对胰腺β细胞的选择性高于心脏和动脉平滑肌细胞的 KATP 通道。

Gliclazide (Standard) 是 Gliclazide 的标准品，适用于定量分析、质量控制及生化实验等相关研究。Gliclazide (SE1702) 是一种有效的全细胞的 β 细胞 ATP 敏感型钾流阻断剂，IC50为 184 nM，用作降糖药。

Norfluoxetine-D5 hydrochloride is intended for use as an internal standard for the quantification of norfluoxetine by GC- or LC-MS. Norfluoxetine is an active metabolite of the antidepressant fluoxetine. It is formed from fluoxetine by the cytochrome P450 (CYP) isoforms CYP2C9,CYP2C19,and CYP3A. Norfluoxetine inhibits serotonin (5-HT)uptake in rat brain synaptosomal membrane preparations (Ki = 44.7 nM)and isolated human platelets (IC50 = ~15 nM). It has been found in the tissues of fish exposed to wastewater effluent.

Gliclazide is a whole-cell beta-cell ATP-sensitive potassium currents blocker with an IC50 of 184 nM. Ethyl tosylcarbamate is an intermediate in the synthesis of Gliclazide (G409877).

Hypoglycemic agent 4 (Compound 5b) 是一种具有口服降血糖活性的四氢吖啶衍生物。该化合物对糖尿病的重要靶点DPP-IV、SGLT1和GLUT2显示良好的结合亲和力，并能够抑制葡萄糖扩散。它在降低Streptozotocin诱导的糖尿病大鼠的空腹血糖方面，其效果与Gliclazide相当。Hypoglycemic agent 4 可用于2型糖尿病的研究。