gi2 261520

Tinostamustine, also known as EDO-S101, is an alkylatlng histone-deacetylase inhibitor (HDACi) fusion molecule. EDO-S101 is a functional pan-histone-deacetylase inhibitor and is assumed to potentiate the alkylating activity of the compound and or may help to overcome resistance to other therapeutic agents.

EDO-S101 (Tinostamustine) 是一种泛 HDAC 抑制剂，IC50为 6 nM，对 HDAC1、HDAC2 和 HDAC3 的 IC50 值分别为 9、9 和 25 nM。