购物车
  • 全部删除
  • TargetMol
    您的购物车当前为空
筛选
已筛选:全部清除
TargetMol | Tags 通过 靶点 筛选
  • Transferase
    (1)
  • Others
    (1)
TargetMol | Tags 通过 货期 筛选
  • 现货
    (1)
  • 8-10周
    (1)
筛选
搜索结果
TargetMol产品目录中 "

ggti-2133

"的结果
  • 抑制剂&激动剂
    2
    TargetMol | Inhibitors_Agonists
  • GGTI-2133
    GGTI2133, GGTI 2133
    T24088191102-79-1In house
    GGTI-2133 是一种有效的仿肽基香叶基转移酶 I 型抑制剂(GGTase I),IC50值为38 nM。GGTI-2133 可抑制小鼠实验性哮喘中炎症细胞向气道的侵袭。
    • ¥ 2480
    In stock
    规格
    数量
    TargetMol | Inhibitor Sale
  • GGTI 2133 TFA
    T851801217480-14-2
    GGTI 2133, a peptidomimetic inhibitor of geranylgeranyl transferase type I (GGTase I; IC50= 38 nM), exhibits 140-fold selectivity towards GGTase I compared to farnesyltransferase (IC50= 5,400 nM). The compound effectively inhibits the geranylgeranylation of RAP1A (IC50= 10 µM) without affecting the farnesylation of H-Ras (IC50= >30 µM). Moreover, GGTI 2133 reduces the growth, migration, and invasion of oral squamous cell carcinoma (OSSC) cells to 75, 45, and 27% of control levels, respectively. When administered intraperitoneally at 5 mg/kg per day, it prevents eosinophil infiltration into the airways in a mouse model of allergic bronchial asthma, although it does not reduce chemokine levels. Additionally, GGTI 2133 thwarts naloxone-induced contraction of ileum in rats experiencing morphine withdrawal syndrome and mitigates the severity of withdrawal symptoms in vivo (ED50= 0.076 mg/kg).
    • 待询
    8-10周
    规格
    数量