genotoxicity

Skimmianine (Chloroxylonine) 是一种呋喹啉类生物碱，主要存在于芸香科，具有抗炎、抗痉挛和抗血小板聚集活性。它对多种癌细胞系具有细胞毒性和基因毒性。

Methyl eugenol (4-allylveratrole) 是一种苯丙类化合物，存在于植物叶子、果实、根茎中，当植物相应的部位因食草动物进食而受损时，就会释放。它可用于消灭雄性东方果蝇。

N-Ethyl-o-toluidine是一种具有遗传毒性和抗癌潜力的药物，对特定基因改变的酵母菌株具有＞70%的生长抑制作用，还可以作为合成染料的中间体。

Musk tibetine reveals no genotoxicity in the micronucleus test with human lymphocytes and human hepatoma cell lines. Musk tibetene is a nitro musk compound with carcinogenic activity.

Galaxolide 可激发 Estrogen Receptor/ERR 的雌激素活性，同时诱发氧化应激和遗传毒性，增强 EROD 与 GST (Glutathione S-transferase) 的酶活性。

FR900098 是一种抗疟剂，能够抑制 1-脱氧-d-木酮糖-5-磷酸 (DXP) 还原异构酶。FR900098 不具有显著的急性毒性和遗传毒性，也不具备导致染色体断裂或非整倍体的能力。此化合物对 NMRI 小鼠的骨髓红细胞无影响。

Indium(III) chloride 通过诱导细胞凋亡 (apoptosis) 在 RAW264.7 巨噬细胞中引起细胞毒性，导致 DNA 损伤和基因毒性。它能激活 caspase-3、-8 和 -9，并诱导线粒体依赖的细胞凋亡途径。此外，Indium(III) chloride 还以浓度依赖性方式增加活性氧 (ROS) 的产生。

4-hydroxy Nonenal is a lipid peroxidation product derived from oxidized ω-6 polyunsaturated fatty acids such as arachidonic acid and linoleic acid. [1] [2] It exhibits various biological activities such as cytotoxicity, growth inhibiting activity, genotoxicity, and chemotactic activity and has been widely used as a marker of lipid peroxidation.[1][2][3] 4-oxo-2-Nonenal is a more recently identified product of lipid peroxidation.[4][5][6] It actively modifies histidine and lysine residues on proteins and causes protein cross-linking. [7][8] 4-oxo-2-Nonenal also modifies 2’-deoxyguanosine, further implicating lipid peroxidation in mutagenesis and carcinogenesis.[4]

4-hydroxy Nonenal is a lipid peroxidation product derived from oxidized ω-6 polyunsaturated fatty acids, such as linoleic acid and arachidonic acid, that is widely used as a marker of oxidative stress. 4-HNE exhibits various biological activities such as cytotoxicity, growth inhibiting activity, genotoxicity, and chemotactic activity. 4-hydroperoxy 2-Nonenal is the immediate precursor of 4-HNE formed from the cleavage of ω-6 hydroperoxides. Analogous reactions are expected to occur with hydroperoxides from other ω-6 fatty acids, particularly arachidonic acid.

(S)-3-Thienylglycine 是一种噻吩衍生物，可用于研究与噻吩衍生物相似结构的遗传毒性。

Isoliquiritin apioside 可抑制癌细胞和内皮细胞的侵袭和血管生成，显著降低 PMA 诱导的MMP9活性增加，并抑制 PMA 诱导的MAPK 和NF-κB 活化。

Dibromoacetaldehyde, a halogenated byproduct found in drinking water, exhibits genotoxicity.

Antitubercular agent-26 (Compound 32) 是一种口服具有活力的抗结核剂，能够作用于 M. tuberculosisH37Rv 细胞（在细胞外的 IC50: 0.50 μM，细胞内的 IC50: 0.51 μM)。Antitubercular agent-26 具有良好的代谢稳定性，及低心脏毒性风险低，没有遗传毒性。

CYP2C1/CYP2C19-IN-2 是无肝脏毒性和遗传毒性的CYP2C9/CYP2C19强效抑制剂，能够用于研究寨卡病毒 (ZIKV) 感染。

CYP2C9/CYP2C19-IN-1 是无肝脏毒性和遗传毒性的CYP2C9/CYP2C19强效抑制剂，能够用于研究寨卡病毒 (ZIKV) 感染。

PF-05139962 is a novel potent mTOR inhibitor with excellent mTOR biochemical inhibition, cellular potency, kinase selectivity and in vitro ADME properties. PF-05139962 has pS473 and pS6 cellular IC50 = 48 and 6 nM respectively. PF-05139962 has great selectivity against other receptors and kinases. No genotoxicity was observed on this compound and no more than 25% inhibiton was observed for major CYP enzymes (3A4, 1A2, 2C9, 2D6) at 3 uM. This compound has LE = 0.35 and LipE up to 6.8 which is in a very desirable range for a kinase inhibitor.

mTORinhibitor-12（Compound 11）为选择性脑渗透性mTOR抑制剂，无遗传毒性风险，适用于中枢神经系统疾病研究。

Ethyl 3-hexenoate 是菠萝中的挥发性香气成分，是一种 RIFM 香料，目前未检测除遗传毒性和生殖毒性。

Mequindox(MEQ) 是一种抗菌剂。Mequindox 作为DNA 合成的抑制剂，对小鼠具有遗传毒性和致癌性。

Galaxolide(HHCB) (Standard) 是 Galaxolide(HHCB) 的标准品，适用于定量分析、质量控制及生化实验等相关研究。Galaxolide 可激发 Estrogen Receptor/ERR 的雌激素活性，同时诱发氧化应激和遗传毒性，增强 EROD 与 GST (Glutathione S-transferase) 的酶活性。

Mequindox (Standard) 是 Mequindox 的标准品，适用于定量分析、质量控制及生化实验等相关研究。Mequindox(MEQ) 是一种抗菌剂。Mequindox 作为DNA 合成的抑制剂，对小鼠具有遗传毒性和致癌性。

Methyl eugenol (Standard) 是 Methyl eugenol 的标准品。适用于定量分析、质量控制及生化实验等相关研究。Methyl eugenol (4-allylveratrole) 是一种苯丙类化合物，存在于植物叶子、果实、根茎中，当植物相应的部位因食草动物进食而受损时，就会释放。它可用于消灭雄性东方果蝇。

Myricetin 3-O-galactoside (Myricetin 3-O-beta-D-galactopyranoside) 可抑制黄嘌呤氧化酶 (xanthine oxidase; XO) 活性，脂质过氧化并清除自由基。杨梅素3- o -半乳糖苷具有很多作用包括细胞毒性、抗氧化、抗基因毒性、抗感染性、抗炎作用和抗氧化活性，其主要作用是抑制诱导型一氧化氮合酶(iNOS)的合成。Myricetin 3-O-galactoside 抑制脂质过氧化的 IC50 为 160 μg/mL。

Fumitremorgen B is a mycotoxin, it exhibits a certain degree of genotoxicity, it can cause DNA damage in human lymphocytes; it shows an inhibitory activity on the cell cycle progression of mouse tsFT210 cells in the M phase, with the MIC value of 26.1 mic