ganoderic acid dm

Ganoderic acid DM 是一种具有抗雄激素活性的破骨细胞生成抑制剂，可显著抑制 c-Fos 和活化 T 细胞核因子 c1（NFATc1）的表达。Ganoderic acid DM 介导的抑制作用可进一步降低树突状细胞特异性跨膜蛋白（DC-STAMP）的表达，并导致破骨细胞融合减少。因此，Ganoderic acid DM 在涉及破骨细胞分化、骨重塑及雄激素相关信号通路的机制研究中具有重要研究价值，尤其适用于肌肉骨骼系统研究模型中的相关实验。

11-Keto-ganoderic acid DM 是一种天然化合物，可作为天然产物对照品。

23S-hydroxy-11,15-dioxo-ganoderic acid DM is a natural product

11-Oxo-ganoderic acid DM 是一种天然产物，可用作天然产物对照品，用于生命科学相关领域的研究，其产品编号为 TN8553。

The binding affinities of ganoderic acid DM andGanoderic acid ζ (ΔGbind, -16.83 and-10.99 kcal mol-1) are comparable to that of current commercial drug oseltamivir (-23.62 kcal mol-1);Ganoderic acid DM is a potential source of anti-influenza ingredient, with novel binding pattern and advantage over oseltamivir, it has steric hindrance on the 150 cavity of N1 protein, and exerts activities across the H274Y and N294S mutations, is the attractive candidates of novel neuraminidase (NA) inhibitors.Ganoderic acid zeta has cytotoxicity in vitro against Meth-A and LLC cell lines.