gallstone

Glycohyodeoxycholic acid 是一种人体次级胆汁酸猪去氧胆酸的主要代谢物，能够预防胆结石的形成。

β-Muricholic acid (β-MCA) is a murine-specific primary bile acid.[1],[2] Dietary administration of β-MCA reduces HMG-CoA reductase activity in liver microsomes from mice fed a high cholesterol and cholic acid diet.[3] Dietary administration of β-MCA also dissolves 100% of gallstones in a gallstone-susceptible mouse model of diet-induced cholesterol gallstones.[4]

SSTR5agonist 3（Compound 23）作为一种SSTR5（生长抑素受体亚型 5）拮抗剂，展示了低hERG抑制作用及良好的口服活性。其在人体和小鼠中的IC50值分别为2.8 nM和1.4 nM。SSTR5agonist 3主要应用于抗胆结石研究领域。