fotemustine

Fotemustine is a chloroethylating nitrosourea with antineoplastic activity. Fotemustine alkylates DNA in cells, resulting in inhibition of DNA synthesis, cell cycle arrest, and finally apoptosis. This agent is lipophilic and crosses the blood-brain barrie

EAPB-0202，EAPB0203的去甲基化代谢产物，表现出相比参考用药fotemustine和imiquimod，对A375具有显著的体外活性。