Folitixorincalcium, (6R)- is the calcium salt of Folitixorin, a substrate used by the enzyme methylenetetrahydrofolate reductase to generate 5-methyltetrahydrofolate.
ANX-510 is a folate-based biomodulator. It stabilizes the covalent binding of the fluorouracil metabolite FdUMP to thymidylate synthase, which results in inhibition of thymidylate synthase, depletion of thymidine triphosphate (TTP), a necessary constituen