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TWS-119 is an inhibitor of glycogen synthase kinase-3β (GSK-3β) that induces neuronal differentiation in pluripotent murine embryonal carcinoma cells and embryonic stem cells (ESCs).

TWS119 是一种GSK-3β特异性抑制剂，IC50值为 30 nM，它可激活 wnt/β-catenin 信号通路，能够诱导神经元分化。