fipi hcl

FIPI is an effective and selective phospholipase D inhibitor that reduces mercury-induced lipid signaling and thus protects aortic endothelial cells from cytotoxicity.

FIPI (5-Fluoro-2-indolyl deschlorohalopemide) 是 halopemide 的衍生物，抑制PLD1和PLD2，IC50值分别为 25 nM 和 20 nM。它防止 PLD 调节 F-肌动蛋白细胞骨架重组、细胞扩散和趋化性。