fibroblast activation protein (fap)

FAPI-2 是一种基于放射性示踪剂 FAP 标记的成纤维细胞活化蛋白特异性抑制剂，具有抗癌活性，可用于研究胰腺癌。

FAP targeting peptide for FXX489是FXX489的多肽部分，可用于生物化学实验和药物合成研究。FXX489是一种成纤维细胞活化蛋白 (FAP) 靶向配体，用于多种癌症的放射性配体疗法（RLT）。

FAPI-4 是一种成纤维细胞激活蛋白 (FAP) 抑制剂，是FAPI配体，在原发性肝癌肝细胞癌（HCC）的PET成像中显示出强烈的肝脏摄取作用，常用于 PET 成像，可用于研究癌症。

FAPI-mFS，作为一种不可逆的成纤维细胞活化蛋白 (FAP) 抑制剂，通过与FAP形成共价结合来提高在癌细胞中的摄取与滞留。此化合物在标记放射性68Ga或177Lu后，可应用于癌症的成像与治疗领域。

3BP-3580 是一种靶向成纤维细胞活化蛋白 (FAP) 的抑制剂 (pIC50: 8.6)，适用于癌症研究。

QI-18 是一种成纤维细胞激活蛋白 (FAP) 的抑制剂，其IC50值为0.50 nM，活性是UAMC-1110 (IC50 3.25 nM) 的6.5倍。QI-18 可用于合成高肿瘤选择性和高剂量的放射性示踪剂，应用于肿瘤的诊断和治疗。

FAPtargeting peptide-PEG2 conjugate (Example A1) 是一种由Unlabeled FXX489的多肽和linker组成的偶联物。Unlabeled FXX489 是针对成纤维细胞活化蛋白 (FAP) 的靶向配体。

DOTAGA-FAP-2286-ALB 是 Rofapitide tetraxetan 的衍生物，是一种靶向成纤维细胞活化蛋白 (FAP) 的选择性抑制剂，IC50为67.5 nM。通过与白蛋白的相互作用，DOTAGA-FAP-2286-ALB 增强了肿瘤中的滞留时间，延长了在血液中的循环时间，并提高了放射性金属复合物的稳定性（如111In和225Ac）。该化合物有潜力应用于FAP阳性实体瘤的放射性核素治疗 (TRT) 研究。

PNT6555 是一种成纤维细胞活化蛋白-α (FAP) 抑制剂，具有抗肿瘤活性，可用于FAP阳性肿瘤的显像。

FAP-IN-4 (Comp 10) 是成纤维细胞活化蛋白 (FAP) 的抑制剂，同时也是靶向FAP的18F标记PET示踪剂，可用于肿瘤研究。

ARI-3099 inhibits fibroblast activation protein, alpha (FAP).

Talabostat (PT100, Val-boroPro) is a potent, nonselective and orally available dipeptidyl peptidase IV (DPP-IV) inhibitor with a Ki of 0.18 nM. Talabostat is a nonselective DPP-IV inhibitor, inhibiting DPP8/9, FAP, DPP2 and some other DASH family enzymes essentially as potently as it inhibits DPP-IV[1]. Talabostat stimulates the immune system by triggering a proinflammatory form of cell death in monocytes and macrophages known as pyroptosis. The inhibition of two serine proteases, DPP8 and DPP9, activates the proprotein form of caspase-1 independent of the inflammasome adaptor ASC[2]. Talabostat competitively inhibits the dipeptidyl peptidase (DPP) activity of FAP and CD26/DPP-IV, and there is a high-affinity interaction with the catalytic site due to the formation of a complex between Ser630/624 and the boron of talabostat[3]. Talabostat can stimulate immune responses against tumors involving both the innate and adaptive branches of the immune system. In WEHI 164 fibrosarcoma and EL4 and A20/2J lymphoma models, PT-100 causes regression and rejection of tumors. The antitumor effect appears to involve tumor-specific CTL and protective immunological memory. Talabostat treatment of WEHI 164-inoculated mice increases mRNA expression of cytokines and chemokines known to promote T-cell priming and chemoattraction of T cells and innate effector cells[3]. Talabostat treated mice show significant less fibrosis and FAP expression is reduced. Upon PT100 treatment, significant differences in the MMP-12, MIP-1α, and MCP-3 mRNA expression levels in the lungs are also observed. Treatment with PT100 in this murine model of pulmonary fibrosis has an anti-fibro-proliferative effect and increases macrophage activation[4]. [1]. Connolly BA, et al. Dipeptide boronic acid inhibitors of dipeptidyl peptidase IV: determinants of potencyand in vivo efficacy and safety. J Med Chem. 2008 Oct 9;51(19):6005-13. [2]. Okondo MC, et al. DPP8 and DPP9 inhibition induces pro-caspase-1-dependent monocyte and macrophage pyroptosis. Nat Chem Biol. 2017 Jan;13(1):46-53. [3]. Adams S, et al. PT-100, a small molecule dipeptidyl peptidase inhibitor, has potent antitumor effects and augments antibody-mediated cytotoxicity via a novel immune mechanism. Cancer Res. 2004 Aug 1;64(15):5471-80. [4]. Egger C, et al. Effects of the fibroblast activation protein inhibitor, PT100, in a murine model of pulmonary fibrosis. Eur J Pharmacol. 2017 Aug 15;809:64-72.

FAPI-46是一种基于喹啉的成纤维细胞激活蛋白（FAP）放射性示踪剂，属于FAP抑制剂（FAPi）,能够和68Ga或177Lu等标记物偶联，在正电子发射断层扫描（PET）中作为示踪剂表达FAP肿瘤。

OncoFAP acetate是一种超高亲和力的FAP（fibroblast activation protein）配体，其解离常数为680 pM,可以靶向fap阳性肿瘤，能够与人FAP结合并与该蛋白的小鼠异构体发生交叉反应。。

BR103354 is a novel fibroblast activation protein (FAP) inhibitor with anti-diabetic and anti-steatotic effects. BR103354 inhibited FAP with an IC50 value of 14 nM, showing high selectivity against dipeptidyl peptidase (DPP)-related enzymes and prolyl oligopeptidase (PREP). BR103354 exhibited good pharmacokinetic properties as evidenced by oral bioavailability of 48.4% and minimal hERG inhibition. Single co-administration of BR103354 with hFGF21 reduced nonfasting blood glucose concentrations, in association with increased intact form of hFGF21 in ob/ob mice. BR103354 acts as an effective FAP inhibitor in vitro and in vivo, thereby demonstrating its potential application as an anti-diabetic and anti-NASH agent.

NOTA-FAPI-4 is an analogue of FAPI-4 and a fibroblast activation protein (FAP) inhibitor. NOTA-FAPI-4 is useful in the diagnosis or treatment of a disease characterized by overexpression of fibroblast activation protein (FAP). NOTA-FAPI-4 can be used as a PET tracer for detection of diseases or disorders related to fibroblast activation protein.

Suc-Gly-Pro-AMC 是一种成纤维细胞活化蛋白 (FAP) 特异性底物。Suc-Gly-Pro-AMC 可用于研究 FAP 的活性。

FSDD0I为一种与白蛋白结合的成纤维细胞活化蛋白(FAP)配体，能够与68Ga和177Lu标记，用于单光子发射计算机断层扫描(SPECT)成像。

FSDD1I为白蛋白结合成纤维细胞活化蛋白(FAP)配体，可68Ga和177Lu标记，用于单光子发射计算机断层扫描(SPECT)成像。

FSDD3I 是一种配体，特别是针对白蛋白结合成纤维细胞活化蛋白 (FAP) 的。它能够以68Ga 和177Lu 进行标记，进而应用于单光子发射计算机断层扫描 (SPECT) 成像技术。

Rofapitide tetraxetan(FAP-2286)是一种高亲和力和选择性的FAP（成纤维细胞活化蛋白）抑制剂和DOTA-pseudopeptide（假肽），IC50=1.3~2.2 nM。FAP-2286靶向肿瘤微环境，可以进行放射性标记（如68 Ga）并用于正电子发射断层扫描（PET）成像。

FAP-2286 acetate，一种与成纤维细胞活化蛋白(FAP)结合的肽偶联物，可通过放射性核素标记进行诊断应用，并展现出抗肿瘤活性。

FAP-IN-2 TFA为99mTc标记的异腈类FAP抑制剂衍生物，适用于肿瘤显像。

SP-13786 是成纤维细胞活化蛋白 (FAP)和脯氨酰寡肽酶 (PREP)的抑制剂，IC50值分别为3.2 nM和1.8μM。