Ezetimibe-D4,a deuterium-labeled variant of Ezetimibe (T1593),functions as an inhibitor of Niemann-Pick C1-like1 (NPC1L1)and is recognized for its potent activation of Nrf2.
Desfluoro-ezetimibe is the defluorinated impurity of ezetimibe. Ezetimibe is an effective, metabolically stable cholesterol absorption inhibitor. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor and an effective Nrf2 activator.