eosinophil proliferation

Mepolizumab (SB 240563) 是一种中和 IL-5 的人源化单克隆抗体。 美泊利单抗可用于严重嗜酸性哮喘和嗜酸性肉芽肿伴多血管炎的研究。

TAK-661 是一种抑制嗜酸性粒细胞趋化性 (eosinophil chemotaxis) 的化合物。该化合物能有效缓解晚期支气管收缩，并抑制在支气管肺泡灌洗 (BAL) 过程中嗜酸性粒细胞的增多，以及其向气道壁的浸润。

1,1'-Ethylidene-bis-(L-tryptophan) is a potential impurity in L-tryptophan commercial products, promoting EoL-3 eosinophilic leukemia cell proliferation, enhancing eosinophil cationic protein release from human peripheral blood eosinophils, and boosting IL-5 production in human T cells. At 40 µg kg, it triggers fascia thickening, mast cell infiltration, inflammation, and fibrosis in mouse superficial adipose and panniculus carnosus tissues, serving as an eosinophilia-myalgia syndrome research model.