endosulfan i

Endosulfan I是广谱杀虫剂Endosulfan的两种主要立体异构体之一，对GABA/benzodiazepine/picrotoxin复合物具有抑制活性(IC50=30 nM)，能够破坏斑马鱼胚胎发育。

Endosulfan II, an organochlorine insecticide and a stereoisomer of Endosulfan I, effectively targets various insects such as bollworms and tobacco budworms, with lethal doses (LD50s) of 4.14 and 4.95 mg g, respectively. It interacts with GABA receptors in rat brain membranes, demonstrating an inhibition concentration (IC50) of 60 nM. Notably, Endosulfan II exhibits lower toxicity in rats compared to Endosulfan I, with LD50 values of 240 and 18 mg kg, respectively.