emerging viruses

STING agonist C11 is an agonist of the stimulator of interferon genes (STING) pathway.1 It induces secretion of type I IFN from THF and MM6 cells when used at a concentration of 50 μM. STING agonist C11 induces phosphorylation of IFN regulatory factor 3 (IRF3) and increases expression of IFIT1 and viperin, but not IL-1β, IL-6, or IL-8 in THF cells in a STING-dependent manner. It reduces viral titers of chikungunya, Venezuelan equine encephalitis, o'nyong-nyong, Mayaro, and Ross River viruses grown in THF cells (EC90s = 16.44, 16.7, 18.84, 25.19, and 22.57 μM, respectively), an effect that is dependent on the presence of STING and the IFN-α β receptor (IFNAR).References1. Gall, B., Pryke, K., Abraham, J., et al. Emerging alphaviruses are sensitive to cellular states induced by a novel small-molecule agonist of the STING pathway. J. Virol. 92(6), e01913-01917 (2018). STING agonist C11 is an agonist of the stimulator of interferon genes (STING) pathway.1 It induces secretion of type I IFN from THF and MM6 cells when used at a concentration of 50 μM. STING agonist C11 induces phosphorylation of IFN regulatory factor 3 (IRF3) and increases expression of IFIT1 and viperin, but not IL-1β, IL-6, or IL-8 in THF cells in a STING-dependent manner. It reduces viral titers of chikungunya, Venezuelan equine encephalitis, o'nyong-nyong, Mayaro, and Ross River viruses grown in THF cells (EC90s = 16.44, 16.7, 18.84, 25.19, and 22.57 μM, respectively), an effect that is dependent on the presence of STING and the IFN-α β receptor (IFNAR). References1. Gall, B., Pryke, K., Abraham, J., et al. Emerging alphaviruses are sensitive to cellular states induced by a novel small-molecule agonist of the STING pathway. J. Virol. 92(6), e01913-01917 (2018).

EB-0150 是一种 ER α-葡萄糖苷酶 (α-Glu) I (IC50s: 0.73 μM) 和 (α-Glu) II (IC50s: 0.0337 μM) 的有效抑制剂。EB-0150 是一种 N-取代的缬草胺衍生物，具有广谱抗病毒效果。EB-0150 针对现有和新兴病毒的广谱药物具有研究潜力。

EB-0156 是一种有效的 ER α-葡萄糖苷酶 (α-Glu) I 和 II 的有效抑制剂，其 IC50 值分别为 0.0479 和 <0.001 μM。EB-0156 是一种 N-取代的缬草胺衍生物，具有广谱抗病毒活性。EB-0156 具有潜力进行针对现有和新兴病毒的广谱药物的研究。

EB-0176 是 N-取代的缬草胺衍生物，表现出广谱抗病毒活性，是一种有效的 ER α-葡萄糖苷酶 (α-Glu) I 和 II 抑制剂，其 IC50s 值分别为 0.6439 和 0.0011 μM。EB-0176 表现出针对现有和新兴病毒的广谱药物的研究潜力。