egf816

Nazartinib mesylate is a novel, covalent mutant-selective inhibitor of EGFR (Ki and Kinact: 31 nM and 0.222 min on EGFR(L858R 790M) mutant).

Nazartinib (EGF816) 是一种共价、不可逆、突变选择性 EGFR 抑制剂，对激活 mt (L858R, ex19del) 和 T790M mt 具有纳摩尔抑制效力，在体外其选择性比野生型 (wt) EGFR 高 60 倍。

Nazartinib is an EGFR inhibitor. Nazartinib S-enantiomer is the less active S-enantiomer of Nazartinib.