eg5 mitotic motor protein

ARQ 621 是一种变构和选择性 Eg5 有丝分裂运动蛋白抑制剂，具有抗肿瘤活性。

NVP-BQS481 (Compound 1) 是一种高选择性的纺锤体驱动蛋白 5 (Eg5) 抑制剂，其IC50小于0.5 nM。NVP-BQS481 展示了强大的抗有丝分裂和抗肿瘤活性（对 SK-OV-3ip 细胞的IC50为0.09 nM）。该化合物适合作为合成抗体-药物偶联物 (ADCs) 的细胞毒性有效载荷。

AZD4877 is a synthetic kinesin spindle protein (KSP) inhibitor with potential antineoplastic activity. KSP inhibitor AZD4877 selectively inhibits microtubule motor protein KSP (also called kinesin-5 or Eg5), which may result in the inhibition of mitotic spindle assembly; activation of the spindle assembly checkpoint; induction of cell cycle arrest during the mitotic phase; and cell death in tumor cells that are actively dividing. Because KSP is not involved in postmitotic processes, such as neuronal transport, this agent may be less likely to cause the peripheral neuropathy often associated with the tubulin-targeting agents. Eg5 is essential for the formation of bipolar spindles and the proper segregation of sister chromatids during mitosis.