echinocandin b

Echinocandin B is a cyclic hexapeptide echinocandin antibiotic from Aspergillus nidulans var. echinulatus . It attacks the cell wall of fungi by inhibiting beta-1,3-glucan synthesis.

Tetrahydroechinocandin B is a cyclic hexapeptide containing a fatty acyl side chain. It also inhibits 1,3-beta-D-glucan synthesis.

ECBN HCL (A-30912A nucleus hydrochloride) 是一种 Echinocandin B 脱酰酶催化反应的产物。

FR901379 is an echinocandin-like antifungal lipopeptide.1 It is active against C. albicans, C. krusei, C. tropicalis, C. utilis, A. fumigatus, and A. niger fungi (IC50s = <0.003-1.9 μg ml). FR901379 is protective against C. albicans infection in mice (ED50 = 1.1 mg kg). It also reduces the number of pulmonary cysts and trophozoites in a mouse model of P. carinii infection. |1. Fujie, A., Iwamoto, T., Sato, B., et al. FR131535, a novel water-soluble echinocandin-like lipopeptide: Synthesis and biological properties. Bioorg. Med. Chem. Lett. 11(3), 399-402 (2001).