e3 ligase ligand 23

E3 ligase Ligand 23 是一种 cereblon 结合剂，可通过泛素蛋白酶体降解 Ikaros 或 Aiolos。

Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2 is a synthesized conjugate compound known as an E3 ligase ligand-linker. It incorporates a cereblon ligand based on Thalidomide and a 3-unit PEG linker. This compound is specifically designed for use in PROTAC technology applications.

(S,R,S)-AHPC-Ala-CO-cyclohexene-Bpin 属于 E3 泛素酶配体+连接子偶联物 (E3 Ligase Ligand-Linker Conjugates) 类型。此化合物主要应用于制备 PROTAC SMARCA2 4-degrader-23。