dtp3

DTP3 是一种选择性 MKK7 GADD45β 抑制剂，靶向 NF-κB 通路，可抑制癌症。

DTP3 TFA (1809784-29-9 free base) (DTP3 TFA) 是一种有效的选择性 GADD45β MKK7（生长停滞和 DNA 损伤诱导型 β 丝裂原活化蛋白激酶激酶 7）抑制剂。

DTP348 is an oral dual CAIX inhibitor radiosensitizer. DTP 348 is an oral dual drug with two mechanisms of action: (1). carbonic anhydrase IX inhibitor which acidifies the intracellular pH through the sulfamide components; (2). radio sensitizer of hypoxic cells through its 5-nitroimidazole moiety.

CRV431 is a novel Pan-Cyclophilin Inhibitor, potently inhibiting all cyclophilin isoforms tested - A, B, D, and G (IC50 values ranged from 1-7 nM).

SP 600125, negative control 是 SP 600125 的甲基化类似物，可用作SP 600125的阴性对照，对 DTP3和GADD45β MKK7（生长停滞和 DNA 损伤诱导型 β 介原活化蛋白激酶激酶 7）具有抑制作用，能够恢复活化。SP 600125, negative control 对 JNK2 和 JNK3 的 IC50s 分别为 18 和 24 μM。