dota peg5 azide

DOTA-PEG5-azide is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

DOTA-PEG5-C4-DBCO 是一种基于 PEG 的连接子，应用于 PROTAC 构建及生物偶联研究，利用应变促进的叠氮–炔环加成（SPAAC）化学反应实现连接。DOTA-PEG5-C4-DBCO 的设计支持功能性配体的偶联，通过泛素–蛋白酶体系统促进靶向蛋白降解，并有助于高级化学探针的模块化组装。

DOTA-(t-butyl)3-PEG5-azide is a polyethylene glycol (PEG) derived linker designed specifically for the synthesis of proteolysis targeting chimeras (PROTACs)[1].