dkfz251

BAY-707 is a substrate-competitive, highly potent and selective inhibitor of MTH1. Despite superior cellular target engagement and pharmacokinetic properties, inhibition of MTH1 with BAY-707 resulted in a clear lack of in vitro or in vivo anticancer efficacy either in mono- or in combination therapies.

DKFZ-251是一种强效选择性的 p38 MAPK 抑制剂。它通过阻断 p38 信号通路抑制促炎细胞因子的释放，表现出显著的抗炎活性，常用于炎症性疾病及癌症治疗的机制研究。