desmethyl qca276

Desmethyl-QCA276, the QCA276-based moiety, binds to cereblon ligand via a linker to form PROTAC to degrade BET. QCA276 is a BET inhibitor with an IC50 of 10 nM, and with a Ki of 2.3 nM[1].

Target Protein Ligand-Linker Conjugates2 由 Desmethyl-QCA276 与相对应的 Linker 缀合而成，构成一种针对靶蛋白的配体-连接子缀合物。此化合物应用于合成 PROTACBD-9136。