desire

Flibanserin (Girosa) 一种具有口服活性的 5-HT1A 受体激动剂和 5-HT2A 受体拮抗剂，Ki 值分别为 1 和 49 nM。它与多巴胺 D4 受体结合，Ki 值在 4 到 24 nM 之间。它是一种血清素能抗抑郁药，用于治疗性欲减退症。

Pinolenic acid is a polyunsaturated fatty acid found in Korean pine (Pinus orientalis) and maritime pine (Pinus pinaster) seed oils. Both oils have been found to have lipid-lowering properties. A diet containing maritime pine seed oil (MPSO) lowered high-density lipoprotein and ApoA1 levels in transgenic mice expressing human ApoA1. MPSO was found to diminish cholesterol efflux in vitro. Korean pine seed oil supplements may help in obesity by reduction of appetite. People taking this oil had an increase in the satiety hormones CCK and GLP-1 and a reduced desire to eat. The activity of the oil is attributed to pinolenic acid. Pinolenic acid is not converted to arachidonic acid metabolically and can reduce arachidonic acid levels in the phosphatidylinositol fraction of HepG2 cells from 15.9% to 7.0%. Pinolenic acid ethyl ester is a neutral, more lipophilic form of the free acid.

Flibanserin (BIMT-17; BIMT-17BS) hydrochloride 是一种口服具有活力的 5-羟色胺的 5-HT1A 受体激动剂 (Ki: 1 nM) 和 5-HT2A (Ki: 49 nM) 受体拮抗剂。Flibanserin hydrochloride 同时可以结合多巴胺 D4 受体 (Ki: 4-24 nM)。Flibanserin hydrochloride 具有抗抑郁和抗焦虑的效果，能够用于性欲减退 (HSDD) 的研究。

Orenetide为旨在HSDD（性欲减退症）治疗中恢复伴随功能的研究用多肽。

Flibanserin-d4-1 是 Flibanserin 的氘代化合物。Flibanserin (BIMT-17) 是一种完全激动 5-羟色胺(5-HT1A)受体的化合物，具有 Ki = 1 nM 的亲和力，同时作为 5-HT2A 拮抗剂显示出 49 nM 的亲和力。Flibanserin 能与多巴胺 D4 受体结合，其 Ki 值为 4-24 nM，而对其他各种神经递质受体和离子通道的亲和力则相对较低。Flibanserin 在性欲减退(HSDD)研究中展现出潜在应用价值。