Desacetylcefotaxime is an active metabolite of the cephalosporin antibiotic cefotaxime .1It is active against 60 clinical isolates derived from patients with meningitis, includingH. influenzae,S. pneumoniae,S. agalactiae, andN. meningitidis(MIC90s = 0.008-0.12 μg/ml). 1.Jones, R.N.Cefotaxime and desacetylcefotaxime antimicrobial interactions. The clinical relevance of enhanced activity: A reviewDiagn. Microbiol. Infect. Dis.22(1-2)19-33(1995)