denibulin

Denibulin (MN-029) is a novel vascular-disrupting agent that reversibly inhibits microtubule assembly, resulting in disruption of the cytoskeleton of tumor vascular endothelial cells. The results of preclinical study demonstrated that MN-029 could cause rapid vascular shutdown in solid tumors, dose-dependent secondary tumor cell killing, and effective enhancement of the antitumor effects of radiation and cisplatin chemotherapy.

Denibulin 是一种血管破坏剂，通过可逆性抑制微管组装来破坏肿瘤血管内皮细胞的细胞骨架。Denibulin 显示出良好的耐受性和潜在的抗血管作用，可用于癌症研究。