7-Oxodehydroabieticacid is a diterpene resin acid found in the roots of Pinus densiflora pine. It acts as a defensive compound against herbivorous insects by disrupting their endocrine system.
12,14-Dichlorodehydroabieticacid, a chlorinated resin acid, exhibits potent calcium-activated potassium (BK) channel opening activity. It effectively inhibits GABA-dependent chloride influx in the mammalian brain, functioning as a non-competitive antagonist of GABA A receptors. Moreover, 12,14-Dichlorodehydroabieticacid induces an elevation in cytosolic free calcium levels and promotes the release of neurotransmitters.