defensin hnp-1 human

Defensin HNP-1 human is a Human neutrophil peptides (HNPs), involved in endothelial cell dysfunction at the time of early atherosclerotic development.Defensin HNP-1 human can regulate the growth of atherosclerosis.

Defensin HNP-1 human TFA，一种人中性粒细胞肽(HNPs)，在早期动脉粥样硬化发展中涉及内皮细胞功能障碍。该化合物展现出广泛的抗菌及抗利什曼原虫活性。

Defensin HNP-3 is a peptide secreted by human polymorphonuclear leukocytes (PMNs) that has antimicrobial properties. It induces lysis of mammalian cells when used at a concentration of 25 μg mL. It also inhibits growth of E. faecalis (ED50 = 100 nM) and clinical isolates of P. aeruginosa (MIC90 = 4 μM). HNP-3 binds to recombinant HIV-1 envelope glycoprotein (gp120) and human CD4 (Kds = 52.8 and 34.9 nM, respectively). It also binds to recombinant, immobilized human surfactant protein D (SP-D; Kd = 55.7 nM) and inhibits focus formation in Madin-Darby canine kidney (MDCK) cells infected with influenza A virus (IAV).

Defensin HNP-1, human acetate是一种主要存在于中性粒细胞中的抗菌肽和人α -防御素，对细菌和病毒具有广谱抗菌活性，可以触发NF-κB和IRF1从而增加IFN-α，能够诱导肿瘤细胞凋亡，抑制血管内皮细胞功能，介导感染免疫等等。

Defensin HNP-3 human 是一种具有抑制金黄色葡萄球菌、铜绿假单胞菌和大肠杆菌活性的细胞毒性抗生素肽。该肽原先以94个氨基酸的preproHNP(1-94)形式合成，随后水解为proHNP(20-94)，最终通过去除阴离子前体转化为成熟形式的HNP(65-94)。