debio 1450

SC 53606 is a potent and selective antagonist of 5-hydroxytryptamine4 receptor.

Afabicin is the prodrug of Debio1452. Debio1452 is an inhibitor FabI, an enzyme critical to fatty acid biosynthesis in staphylococci.

Afabicin (formerly Debio 1450, AFN-1720) is a prodrug of afabicin desphosphono, an enoyl-acyl carrier protein reductase (FabI) inhibitor, and is a first-in-class antibiotic with a novel mode of action to specifically target fatty acid synthesis in Staphylococcus spp.

Afabicin (Debio 1450) 是一种 Debio1452 的前体药物，能够抵抗葡萄球菌 staphylococci，对其他的革兰氏阳性菌和阴性菌无明显作用。其中 Debio1452 是一种 FabI 抑制剂，对葡萄球菌中的脂肪合成具有抑制作用。