ddr-1-in-5

DDR1-IN-5 is a potent and selective inhibitor of the Discoidin Domain Receptor family, member 1 (DDR1). It effectively inhibits the phosphorylation of DDR1b (Y513) with an IC 50 value of 4.1 nM. Furthermore, DDR1-IN-5 demonstrates remarkable anti-cancer activity. Its inhibitory potency against DDR1 (IC 50 = 7.36 nM) makes it a promising compound for targeted therapy in cancer treatment.

Phosphoramide mustard cyclohexanamine（磷酰胺氮芥环己胺盐）是cyclophosphamide的活性代谢物，是一种交联DNA链的烷基化剂，组织细胞分裂并导致细胞死亡，具有抗肿瘤活性。